Study 9
Name of Study: Histamine And Acute Haemorrhagic Lesions In Rat Gastric Mucosa: Prevention Of Stress Ulcer Formation By (=)-Catechin, and Inhibitor Of Specific Histidine Decarboxylase In Vitro
Conducted by: Reimann, Lorenz, Fischer, Fršlich, Meyer and Schmal
Published in: Dirkhauser, Verlay, Basel, Vol. 7/1
Publication date: 1977
Where study conducted: Division of Experimental Surgery and Pathological Biochemistry and Surgery Clinic of the University, Marburg Lahn, Germany
Material used for study: Study was done with (+)-catechin, a monomer constituent of Masquelier's OPC extract from Vitis Vinifera (grape seeds)
In-vivo study: Yes
Category of animal subjects: 1,000 female Sprague Dawley rats
Dosages used: (+)-catechin was administered in a dose of 1-50mg/kg i.p.
Summary/Abstract: (+)-Catechin given intraperitoneally prevented the formation of gastric lesions in the immobilized rat to a large extent. The most effective dose of 25mg/kg decreased the number to erosions/rat by 82 ± 10% in the average (n = 7). 1mg/kg was ineffective, whereas 5mg/kg and 10mg/kg reduced the number of lesions by 10 and 25%, respectively. The most interesting effect, however, was the good reproducibility of the prevention of gastric lesions by (=)-catechin. Seven series of experiments performed during a period of 6 months yielded a reduction of stress ulcer rate by 80%. This strong action by a dose of 25mg/'kg. which is very tolerable in man, defined(=)-catechin as a candidate for clinical trials.
Acknowledgments: Supported by a grant from Deutsche Forschungsgemeinschaft.