Study 8
Name of Study: Inhibitory Effects Of Tannins On Hyaluronidase Activation and On The Degranulation From Rat Mesentery Mast Cells
Conducted by: Hisao Kakegawa, Hitochi Matsumoto, Koichi Endo, Toshio Satoh, Gen-ichiro Nonaka and Itsuo Nishioka
Published in: Chem. Pharm. Bull./No. 11
Publication date: March 4, 1985
Where study conducted: School of Pharmacy, Tokushima University of Arts and Science and Faculty of Pharmaceutical Sciences of Kysuhu University, Japan
Material used for study: The study was done with 1, 2, 3, 4, 6, -penta-O-galloylglucose, 1, 2, 3, 6-tetra-O-galloyiglucose (hydrolyzable tannins) and 3.3-di-O-galloylprodelphinidin B-2 (condensed tannins), procyanidin B-2, (+) -epicatechin, (+)-catechin.
In-vitro study: Yes
Type of tissue: rat mesentery mast cells/Hyaluronidase from bovine testes
Category of animal subjects: rats
Summary/Abstract: The inhibitory effects of tannins on the activation of inactive hyaluronidase and on the degranulation from rat mesentery mast cells induced by compound 48/80 were investigated. Among the tested tannins, 1, 2, 3, 4, 6, - penta-O-galloylglucose, 1, 2, 3, 6- tetra-O-galloyiglucose (hydrolyzable tannins) and 3.3o-di-O-galloylprodelphinidin B-2 (condensed tannins) showed the strongest inhibitory effects in both cases. These results suggest that many tannins may possess anti-inflammatory activity and anti-allergic activity.