Study 7
Name of Study: Action Protectrice Du Vin Sur L'ulcere Gastrique (Protective Action Of Wine Against Gastric Ulcers)
Conducted by: Prof. Jack Masquelier
Published in: Recherches subventionnees par la Conseil Interprofessional du vin de Bordeaux
Where study conducted: Laboratoires de Matieres Medicales, University of Bordeaux, France
Material used for study: Masquelier's OPC extract from Vitis Vinifera (grape seeds)
In-vitro study: Yes
Type of tissue: Histidin decarboxylase (Sigma N.H. 8375)
Dosages used: 10mg/liter in aqueous solution
Summary/Abstract: In 1973, Lorenz found that (=)-catechin had a certain protective action with respect to gastric ulcer in stressed rats. Recently, Parmar has shown that this molecule acts in advance on ulcerous lesions in the stomach due to pylorus ligature, body immobilization and different drugs (aspirin, phenyibutazone, indometacine, reserpine). Those effects of catechin are due to its inhibitory action on histidine-decarboxylase (HD) and so on the excessive production of histamin in gastric mucosa.
Results: Inhibition of HD On ten dosages effectuated in-vitro, expressed in p 100 of their theoretical histamine value, We obtain:
Control test-substance: 92%
OPC test substrate: 6%
Hence, OPC from grapes and from wine is an inhibitor of histidine decarboxyase. In its presence and under the conditions described, the production of histamine is reduced with an average of 85%. This confirms the results obtained by Lorenz and Parmar with (+)-catechin.