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Study 11
Name of Study: Activite Angioprotectrice Des Oligomeres Procyanidoliques Chez L'animal/Activite Antiagoniste Vis-A-Vis Des Mediateurs De L'inflamation (Angioprotective Activity Of Oligomeric Proanthocyanidins In Animals/Antagonistic Activity Against Inflammatory Mediators)
Conducted by: Barbier, Maffrand, Savi, Unkovic, Vilain
Where study conducted: Sanofi-Recherche, Montpellier, France
Material used for study: Masquelier's OPC extract from Vitis Vinifera (grape seeds)
In-vivo study: Yes
Category of animal subjects: hairless rats
Dosages used: 1.5; 1,0; 0.5; g/kg orally
Summary/Abstract: High doses of orally administered OPC significantly reduce reactions induced in hairless rats by means if intradermal reactions of histamine, serotonin bradykinin and dextran in a dose dependent way. The inhibiting effect is slightly superior in the case of histamine and dextran than in cases of serotonin and bradykinin (for example at 1 g/kg: -41, -45, -29 and -25 respectively).