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Fibromyalgia: An oxidative-dysoxygenative disorder

Ali M, Ali O. Fibromyalgia:
An oxidative-dysoxygenative disorder (ODD) Journal of Integrative Medicine 1999;3:17-37
Majid Ali, M.D., Omar Ali,M.D.

From the Department of Integrative Medicine, Capital University of Integrative Medicine, Washington, D.C.(MA); Department of Pathology, College of Physicians and Surgeons of Columbia University, New York (MA); and the Department of Medicine, Institute of Integrative Medicine, New York and Denville, New Jersey (MA and OA).

Excerpt:
An "oxidative-dysoxygenative" disorder (ODD) is proposed as a pathogenetic model for fibromyalgia. This model of molecular dynamics extends beyond the conventional view of the pathophysiology of the muscle and nerve in fibromyalgia, abnormalities which are regarded as epiphenomena in the context of the proposed (ODD) hypothesis. Rather, the proposed model focuses on accelerated oxidative stress (oxidosis), abnormal cellular oxygen metabolism caused by oxidative injury to enzyme pathways involved in redox homeostasis, oxygen transport to tissues and utilization in the cell ("dysoxygenosis"), and acidosis.

Such injury is caused by the cumulative effects of all operant endogenous and exogenous oxidants and results in impaired oxygen transport and utilization as well as cellular anoxia. Oxidosis, dysoxygenosis, and acidosis (the three principal elements of ODD) feed upon each other and create a dysoxygenative state in which the cellular oxygen metabolism is severely hampered and cellular energy pathways are impaired.

The oxidative-dysoxygenative disorder so produced causes (and fully explains) the entire spectrum of symptom-complexes of fibromyalgia. Direct morphologic and biochemical evidence supporting the ODD hypothesis is marshaled. Data obtained with a clinical outcome study of 150 patients with fibromyalgia presented in a companion article in this issue of the Journal provide strong clinical support for the ODD hypothesis.

Read the entire study at http://www.jintmed.com/Fibromyalgia%20ODD.htm

WHAT Fibromyalgia?

"I followed my practitioner's recommendation to take Primary Source OPC GoldBlend® and after a few weeks, my symptoms were gone."

Our customers have had such impressive results with OPC GoldBlend® relieving their symptoms of fibromyalgia, now it is guaranteed to noticeably relieve your symptoms in 30 days when taken as directed. Most patients suffering from symptoms of fibromyalgia have experienced remarkable improvement in overall health within 30 days of starting treatment. Many report becoming symptom-free with diligent daily use of OPC GoldBlend® within six weeks.

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If you are suffering from sore joints and muscles, insomnia and the other symptoms of Fibromyalgia, consider Primary Source OPC GoldBlend® as a primary therapy. Recent studies have shown that oxidative stress may be a leading cause of fibromyalgia (see article at right.) Many patients have found lasting relief from a natural yet powerful antioxidant that mitigates or reverses the symptoms. Primary Source OPC GoldBlend® is a proprietary blend of Masquelier's® Original OPC derived from both grape seed and pine bark. Studies have shown that OPC GoldBlend® containing Dr. Masquelier's OPC has stronger antioxidant capacity than Vitamins C & E, green tea, and other antioxidant supplements. More importantly, unlike other antioxidants, OPC GoldBlend is 100% bio-available and does not become a free radical itself as it neutralizes harmful free radicals in the body.

OPC GoldBlend® produces real results where other grape seed and pine bark products that contain only trace amounts of active OPC fail. Primary Source OPC GoldBlend® has up to 90% more active OPC than other brands.

ORAC, which is an acronym for Oxygen Radical Absorbance Capacity, is a test tube analysis that measures the ability of chemical substances to neutralize oxygen free radicals (antioxidant capacity). The more oxygen radicals a substance can absorb, the higher its ORAC score. Masquelier OPC has consistently scored significantly higher than other grape seed and pine bark extracts.

What is OPC?

Oligomeric Proanthocyanidins (OPC) is a natural, health supporting complex found in practically every plant. It occurs in parts of the plant that are not typically eaten by humans, such as seeds and bark. Many confuse OPC with "grape seed extract" or "pine bark extract." Although certain varieties of grape seed skins and French maritime pine bark naturally contain an abundance of OPC, only a highly specialized process yields the precisely extracted ratio of specific soluble, active components that allow proven preventative and therapeutic health benefits that are potent, pure and non-toxic.

History

In 1947 Dr. Jack Masquelier isolated and named the powerful antioxidant, cellular and tissue membrane protector known today as oligomeric proanthocyanidins (OPC) and went on to spend the rest of his professional life researching medicinal applications for this extraordinary compound (flavan 3,4 diol). Found first in peanut skins, around 1950 he found the bark of Maritime Pine to be an equally good source of OPC. He later found grape seed skins to be an abundant, commercially viable source of the OPC complex.

Dr. Masquelier's OPC has been used for three separate prescription medications in France and world-wide as a dietary supplement. Dr. Masquelier was intrigued with OPC's unique ability to repair, strengthen and protect both collagen and elastin. He was able to show that OPC neutralized the destructive enzymes, collagenace and elastace, and worked with Vitamin C to rebuild and maintain optimum health of collagen and elastin. These effects had pronounced benefits for the heart, veins, arteries, capillaries, skin, muscles, tendons and ligaments in fact all connective tissue.

Dr. Masquelier began researching OPC's strong free radical scavenging effect which led to his obtaining a use patent (4,698,360) in 1987. He demonstrated that not only was his OPC a powerful antioxidant but that it did not have pro-oxidant (becoming a free radical in the process of neutralizing other free radicals) tendencies. This makes it unique among antioxidant compounds.

Primary Source OPC GoldBlend® is 100% natural, safe and does not interfere with other medication or supplements that you may already be taking. GoldBlend® will, however, bond with proteins, so for optimum benefits, we suggest that it be taken on an empty stomach with plenty of water.

Primary Source GoldBlend® is available in two strengths- 50 and 100 mg in bottles of 60 capsules.

For more detailed information including copies of clinical studies, please contact us directly at 1-888-666-1188.